American Cruise Lines has multiple ships that offer Mississippi River cruises out of New Orleans - including modern ships and the classic paddlewheeler American Splendor.
The video below provides a full introduction to a round-trip cruise from New Orleans.
The American Serenade is a thoroughly modern new ship from the exterior to the interior. It's spacious and elegant. It features a 4-story glass atrium, fitness room, yoga studio, study, lounges, restaurant, cafe and sun deck. The staterooms have private balconies.
Good news for solo travelers - the American Serenade has some single staterooms. It's the comfortable way to take a cruise by yourself. The ship also offers suites and generously sized regular staterooms.
Complete Mississippi River cruises go all the way up the river from New Orleans to Minnesota.
21-night Complete Mississippi River cruise. One-way from New Orleans to St Paul (Minnesota). Visit Oak Alley (Louisiana), Houmas House (Louisiana), Baton Rouge (Louisiana), St Francisville (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi), Greenville (Mississippi), Tunica (Mississippi), Memphis (Tennessee), Cape Girardeau (Missouri), St Louis (Missouri), Hannibal (Missouri), Muscatine (Iowa), Dubuque (Iowa), Winona (Minnesota) and Red Wing (Minnesota).
• 2025 departures: May 23, June 13.
Lower Mississippi River cruises are classic one-way voyages from New Orleans to Memphis.
7-night Mississippi River one-way cruises. One-way from New Orleans to Memphis (Tennessee), with stops at Oak Alley (Louisiana), Baton Rouge (Louisiana), Natchez (Mississippi) and Vicksburg (Mississippi).
• 2025 departures: February 21, February 25, March 7, March 11, March 12, March 21, March 25, March 28, April 4, April 8, April 11, April 18, April 22, April 25, May 2, May 6, May 9, May 16, May 20, May 30, June 3, June 17, July 15, August 26, September 26, October 16, October 31, November 4, November 11, November 14, November 25, December 9, December 24.
Mississippi River round-trip cruises offer the convenience of departing and arriving from New Orleans.
6-night Mississippi River cruises. Round-trip cruise from New Orleans to Oak Alley (Louisiana), Baton Rouge (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi) and St Francisville (Louisiana).
• 2025 departures: March 10, March 16, March 22, March 29, April 4, April 10, April 16, April 22, April 28, May 4, May 10, May 16, May 22, May 28, July 1, October 10, October 16, October 22, October 28, November 3, November 9, November 15, November 16, November 22, November 28, December 4, December 10, December 16.
Mississippi Explorer cruises are longer one-way voyages from New Orleans to Memphis.
11-night Mississippi River one-way cruises. One-way from New Orleans to Memphis (Tennessee), with stops at Oak Alley (Louisiana), Baton Rouge (Louisiana), St Francisville (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi), Cleveland (Mississippi) and Tunica (Mississippi).
• 2025 departures: March 26, April 12, October 30.
