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American Cruise Lines New Orleans
Queen of the Mississippi Cruises

American Cruise Lines Mississippi River Cruises from New Orleans

American Cruise Lines has multiple ships that offer Mississippi River cruises out of New Orleans - including modern ships and the classic paddlewheeler American Splendor.

The video below provides a full introduction to a round-trip cruise from New Orleans.

The American Serenade is a thoroughly modern new ship from the exterior to the interior. It's spacious and elegant. It features a 4-story glass atrium, fitness room, yoga studio, study, lounges, restaurant, cafe and sun deck. The staterooms have private balconies.

Good news for solo travelers - the American Serenade has some single staterooms. It's the comfortable way to take a cruise by yourself. The ship also offers suites and generously sized regular staterooms.

Complete Mississippi River Cruises

Complete Mississippi River cruises go all the way up the river from New Orleans to Minnesota.

21-night Complete Mississippi River cruise. One-way from New Orleans to St Paul (Minnesota). Visit Oak Alley Plantation (Louisiana), Houmas House (Louisiana), Baton Rouge (Louisiana), St Francisville (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi), Greenville (Mississippi), Memphis (Tennessee), New Madrid (Missouri), Cape Girardeau (Missouri), St Louis (Missouri), Hannibal (Missouri), Fort Madison (Iowa), Davenport (Iowa), Dubuque (Iowa), Winona (Minnesota) and Red Wing (Minnesota).
• 2022 departures: June 10, July 20, September 10.
• 2023 departures: June 9, August 10.

Mississippi River Gateway Cruises

Mississippi River Gateway cruises are one-way from New Orleans to St Louis.

10-night Mississippi River Gateway cruises. One-way from New Orleans to St Louis. Visit Baton Rouge (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi), Memphis (Tennessee), New Madrid (Missouri) and Paducah (Kentucky).
• 2022 departures: July 27, October 5, October 5.
• 2023 departures: July 1.

Highlights of the Mississippi River Cruises

Highlights of the Mississippi River cruises are short round-trip cruises out of New Orleans.

4-night Highlights of the Mississippi River cruises. Round-trip from New Orleans to Houmas House (Louisiana), Baton Rouge (Louisiana) and Oak Alley (Louisiana).
• 2022 departures: March 20, March 24, March 28, April 1, June 28, July 2, July 23, October 29, November 12, November 16.
• 2023 departures: March 19, March 23, March 27, March 31, November 28, December 2, December 6.

Lower Mississippi River Cruises

Lower Mississippi River cruises are classic one-way voyages from New Orleans to Memphis.

7-night Mississippi River one-way cruises. One-way from New Orleans to Memphis (Tennessee), with stops at Oak Alley Plantation (Louisiana), Baton Rouge (Louisiana), St Francisville (Louisiana), Natchez (Mississippi) and Vicksburg (Mississippi).
• 2022 departures: March 18, March 20, March 26, April 1, April 3, April 9, April 15, April 17, April 23, April 29, May 1, May 7, May 13, May 15, May 17, May 21, May 27, May 29, May 31, June 4, June 12, June 18, June 26, July 2, July 6, August 24, August 27, September 7, September 21, October 9, October 15, October 23, October 29, November 2, November 6, November 12, November 18, November 20, November 26, December 2, December 19, December 20.
• 2023 departures: February 20, February 25, March 3, March 6, March 11, March 17, March 20, March 25, March 31, April 3, April 8, April 14, April 17, April 20, April 22, April 28, May 1, May 4, May 6, May 12, May 15, May 18, May 20, May 26, May 29, June 3, June 12, June 17, July 4, July 18, August 1, August 15, August 29, September 12, September 26, October 10, October 26, October 28, November 11, November 17, November 20, November 25, December 1, December 20.

Round-trip 1-Week Mississippi River Cruises

Mississippi River round-trip cruises offer the convenience of departing and arriving from New Orleans.

7-night Mississippi River cruises. Round-trip cruise from New Orleans to Oak Alley Plantation (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi), St Francisville (Louisiana), Baton Rouge (Louisiana) and Houmas House (Louisiana).
• 2022 departures: February 20, February 27, March 6, March 13, April 5, April 12, April 19, April 26, May 3, May 10, June 14, June 21, July 16, October 2, November 5, November 16, November 20, November 23, November 30, December 4, December 21, December 29.
• 2023 departures: February 19, February 26, March 5, March 12, April 4, April 11, April 13, April 18, April 25, May 2, May 9, May 16, May 23, May 30, June 6, June 13, June 20, June 27, October 21, October 24, October 31, November 2, November 7, November 9, November 13, November 14, November 16, November 21, November 23, November 30, December 4, December 7, December 11, December 14, December 21, December 29.

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